If you are trying to make horsepower Avgas is not the way to go. It is formulated with a rather high vapor pressure and only a moderate caloric value.
To make power your are best with the real race fuels, they are blended to provide a high caloric value, that is a high heat per KG of fuel. The Methanol does this by needing allot of fuel with a fast burn, the race gas does it by burning hot and quick. Avgas is a moderate and slow burn, it wants a more advanced ignition timing to get complete burn.
Problem with more advance is the chamber pressure is rising before TDC so it is pushing down on the piston to early, trying to stop the crank rather than accelerate it. You want the least amount of timing and still get a full burn, this way the pressure is after TDC and pushing the crank the proper way and not trying to stop it as any pressure rise before TDC will be doing.
I came to understand this when I started tuning turbo engines with just 12-13° of timing. The crank keeps getting accelerated.
I would concentrate on getting the most compact chamber with the tightest squish area. The larger the percentage of squish area the quicker the burn in the chamber will will be. Therefore the least time needed to complete the burn.
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