When I read "split the case" I read separating the bottom half of the engine from the top, so as Steve said, more clarification is needed.
"Splitting the cases" most often means separating the bottom end case halves. You need to do this to get to the transmission, crankshaft, etc. This is the terminology used in the manuals.
You can remove the cylinder head and cylinders (the "top end") in the frame without splitting the cases.
But to split the cases (separate the bottom end halves), you must remove the engine from the frame.
You can replace the crankshaft and countershaft and some assorted other seals and o-rings without splitting the cases, so it's unclear what sort of oil leak might require this.
Or perhaps the OP means removing the cylinder head and cylinders, sometimes referred to as the "top end".
So Glib: what exactly is leaking and what work are we talking about here? You mentioned a valve, so can we assume you're talking about a top end?
If you've done it a couple of times before, I'd guess that the disassembly and assembly work of removing and replacing the cylinder head, cylinder, and pistons ("doing the top end") could be done in something like four to six hours, NOT including any cleaning, prep, or scraping. This is assuming you're organized, clean, and invisible gnomes make your parts magically clean the instant you put them down. (I bet the drag racers have this down to two hours or less...)
However, you'll spend at LEAST the same amount of time and probably a LOT more cleaning and scraping, depending on when the engine was apart last, and how well it was prepared at that time. Dealing with crusty diamond-hard 35 year old gaskets is the ridiculously tedious and time-consuming part of GS engine work. They're very simple engines, so disassembly and assembly are the fun, easy parts...
And I haven't even accounted for any time required to deal with broken bolts. If the engine hasn't been apart recently, it's a virtual certainty.
Not to mention all the time acquiring parts, etc. Getting the cylinders back onto the engine over the piston rings is possible with one person, but it's about 100x easier if you can recruit an assistant for a half hour or so.
If you're really talking about "splitting the cases" as in separating the bottom end case halves, then it depends on what you're in there to do. Plus, you can actually split the cases without removing the cylinder head, so perhaps that's an option.